Weight Loss with GLP-1 Medications

What are GLP-1s and How Do They Work?

Glucagon-like peptides (GLP-1) are a class of medications used originally to treat diabetes but have since expanded into the treatment of obesity.

These medications are agonists which mimic the naturally occurring GLP-1 that our gut releases upon eating.

They have the ability to:

• Reduce cravings and appetite
• Slow the rate that the stomach empties food content so the individual feels fuller for a longer period of time
• Lower blood sugar levels by stimulating insulin production in the pancreas 

What are Their Uses and Benefits

For diabetics, GLP-1s improve blood sugar control, reducing the risk of complications. For those experiencing struggles with being overweight, these medications have been a game-changer in promoting weight-loss and improving metabolic health as they suppress the release of glucagon, the hormone that raises blood sugar. These medications also act on the brain’s appetite center to reduce hunger and cravings. 

Other benefits include improved cardiovascular health (reduced risk of heart attack and stroke) as well as kidney protection.

These medications influence Incretin, a metabolic hormone already produced in the intestines. The two most important incretin hormones are Glucagon-like peptide-1 (GLP-1) and Glucose-dependent insulinotropic polypeptide (GIP). 

The issue many overweight, prediabetic or Type-2 diabetic individuals face is an altered incretin response. GLP-1 meds are designed to have a longer duration of action compared to natural GLP-1. This results in a more sustained reduction in blood sugar levels and appetite suppression.

Brand Names & Ingredients

The most common brands of GLP-1s include: Ozempic, Wegovy, and Monjauro.

The active ingredient in Ozempic and Wegovy is Semaglutide. The active ingredient in Monjauro is Tirzepatide.

The ingredient, Semaglutide, influences the body’s GLP-1 while Tirzepatide actively influences not only GLP-1 but also the GIP system. Both have unique functions and play vital roles in metabolic regulation. These multi-faceted effects are beneficial for Type-2 diabetic concerns as well as obesity.  GIP primarily stimulates the release of insulin from the pancreas after eating, as a response to the rise in blood sugar levels.

Which is Right for Me?

The sustained action of GLP-1 medications are designed to have a longer duration of action compared to naturally occurring GLP-1. Both GLP-1 and GIP have unique functions.  Their relative advantages and disadvantages can depend on the context and individual patient factors.

The GIP system primarily stimulates the release of insulin after eating. This is important to facilitate the uptake of glucose into cells.  Its role is to prepare the body to manage incoming nutrients.  In some instances the GIP system may provide rapid and robust insulin release which can be advantageous in controlling post-meal blood sugar spikes.

GLP-1 meds have a broader range of effects. They stimulate insulin secretion, suppress glucagon release (which raises blood sugar) and slow gastric emptying (the rate the food leaves the stomach).  This promotes a feeling of fullness. These multifaceted effects can be quite essential for both blood sugar control and weight management. They also demonstrate additional benefits by reducing the risk of major cardiovascular events such as heart attacks and strokes in people with type 2 diabetes and obesity.

The choice between the GIP system and GLP-1 meds depends on the individual patient characteristics and the condition being treated. It is important to note that these two systems do not compete with each other but rather, complement each others’ actions in the body.

Determining which approach is best should be done with the help of a Healthcare Provider who specializes in this. They can consider the individual’s overall wellness and health goals, as well as responses to previous treatments. 

Additionally, it should be considered that the use of weight-loss medications is only a portion of what is involved for the patient attempting to lose or maintain weight. Other necessary factors include adequate sleep, exercise, mental well-being, water intake, and proper consumption of nutrient-dense foods.  While these medications are extremely helpful in losing weight, it is important for the individual to also address the physical, mental and emotional factors that contributed to their weight gain in the first place. 

For these reasons, it is crucial to consult with a qualified and experienced medical specialist who will factor in your unique circumstances.

 The Medical Providers of Optimal Health and Wellness Center, and its affiliate, Optimal Men’s Center are able to review your health history and current conditions in order to navigate you towards your health goals.  

We offer both Semaglutide and Tirzepatide options along with nutrition guidance, hormone screening, peptide therapy and proper nutraceutical supplementation.

Click below for our contact information and to learn more:

https://www.optimalmenscenter.com/contents/additional-services/weight-loss/semaglutide

Author

Optimal Health and Wellness Center